In addition, the FMF-SAA1 StripAssay further analyzes 2 polymorphic loci in the serum amyloid A1 (SAA1) gene constituting the isoforms SAA1.1, SAA1.3 and SAA1.5. The homozygous condition of SAA1.1 isoform is significantly associated with the occurence of amyloidosis, the most important complication in FMF.
- FMF is the most common inherited inflammatory disorder
- Recurrent bouts of fever and painful inflammation in the abdomen, chest or joints, typically lasting 12 to 72 hours, characterize the condition
- The most severe complication of FMF is amyloidosis, a build-up of protein deposits that ultimately leads to kidney failure
Prophylactic treatment with colchicine can prevent this and allow a normal life
The ViennaLab FMF StripAssays®
• are based on reverse-hybridization of biotinylated PCR products
• combine probes for mutations and controls in a parallel array of allele-specific oligonucleotides
• work with immobilized oligos on a teststrip
• show mutations by enzymatic color reaction easily visible to the naked eye
Application Note: Genetic Testing for Familial Mediterranean Fever in Austria by Means of Reverse-Hybridization Teststrips.
Familiar Mediterranean Fever
|FMF StripAssay®||4-230||20 Tests||Detection of 12 MEFV gene mutations|
|FMF-SAA1 StripAssay®||4-390||20 Tests||Detection of 12 MEFV gene mutations and SAA1 genotypes 1.1, 1.3 and 1.5|