- Most forms of haemochromatosis are caused by mutations in the HFE gene; less common forms carry mutations in the TFR2 or FPN1 gene.
- Haemochromatosis can lead to liver cirrhosis, liver cancer, diabetes, arthritis, and cardiopathies.
- If treatment is started before organs are damaged, these associated conditions can be prevented.
- Premature death or organ failure may occur if the condition is left untreated.
- Therapeutic bleeding is a simple, safe and effective treatment.
- Thus, early diagnosis allows a virtually normal life for affected individuals
The ViennaLab Haemochromatosis StripAssays®
• are based on reverse-hybridization of biotinylated PCR products
• combine probes for mutations and controls in a parallel array of allele-specific oligonucleotides
• work with immobilized oligos on a teststrip
• show mutations by enzymatic color reaction easily visible to the naked eye
|Haemochromatosis StripAssay A||4-220||20 Tests||Detection of 18 mutations: twelve HFE mutations, four TFR2 mutations and two FPN1 mutations|
|Haemochromatosis StripAssay B||4-210||20 Tests||Detection of 3 HFE gene mutations: C282Y, H63D and S65C|