MTHFR 677C>T/1298A>C RealFast™ Assay

Cardiovascular Diseases (CVD) are MTHFR PCRcommon, but in many cases can be avoided.
Atherosclerosis and venous thrombosis are the two major manifestations of CVD. Both are caused by complex interactions of environmental and genetic parameters. MTHFR PCR MTHFR PCR

An unhealthy lifestyle in combination with certain genetic variants can contribute to a therosclerosis. Relevant genes include those involved in endothelial dysfunction, hyperlipidemia, hypertension, and inflammation. A combination of adverse influences (female hormone intake, immobilization, surgery or cancer) and variations in genes responsible for the coagulation system can also lead to thrombosis. Testing for genetic variations and adequate prophylaxis contributes to lower CVD risks.

Two common mutations in the MTHFR gene, 677C>T and 1298A>C, contribute to reduced enzyme activity which leads to elevated levels of homocysteine. Homozygosity for 677C>T or compound heterozygosity for 677C>T / 1298A>C conveys a significantly higher risk for negative side-effects of methotrexate medication. Identification of relevant mutations in the MTHFR gene is crucial for allowing an adequate and safe methotrexate therapy!

Product Cat.CapacityApplication
MTHFR StripAssay®4-35020 testsDetection of the MTHFR gene mutation 677C>T
MTHFR 677C>T RealFast™ Assay7-160100 reactionsDetect common mutations in the methylenetetrahydrofolate reductase (MTHFR) gene causing hyperhomocysteinemia, which is a risk factor for cardiovascular disease
MTHFR 1298A>C RealFast™ Assay7-170100 reactionsDetect common mutations in the methylenetetrahydrofolate reductase (MTHFR) gene causing hyperhomocysteinemia, which is a risk factor for cardiovascular disease

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