FV and PTH are major FV-PTH PCRplayers in the coagulation cascade. The FV Leiden mutation causes a single amino acid exchange at position 506 (R506Q), which alters a cleavage site and thereby prevents efficient inactivation of FV. FV-PTH PCR

The FV-PTH mpx RealFast™ Assay is a fast and accurate multiplex real-time PCR test for the simultaneous detection of the two most important thrombophilic mutations. The point mutation 1691G>A in the human coagulation Factor V (F5) gene, referred to as FV Leiden, and the prothrombin (PTH) 20210G>A mutation in the Factor II (F2) gene are associated with hereditary thrombophilia.

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The kit is intended to test patients suspected of having an increased risk for thrombotic disorders. The qualitative assay discriminates the three possible genotypes for each of the mutations in human genomic DNA: normal, heterozygous or homozygous mutant.

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