For laboratories who want to do more extensive testing into the genotypes associated with the response to 5-fluorouracil therapy, the PGX-5FU XL Stripassay is coming soon, which tests for 4 mutant and wild type genes.
Fluoropyrimidines are widely used for the treatment of various solid tumors. ViennaLab assays identify the most common variants in the dihydropyrimidine dehydrogenase (DPYD) gene with therapeutic relevance for fluoropyrimidine treatment.
A part of fluoropyrimidine-related toxicity arises due to impaired activity of the key metabolic enzyme dihydropyrimidine dehydrogenase (DPD) caused by genetic variants in the DPYD gene.
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