- This hemoglobin disease belongs to the most frequent hereditary diseases posing a major public health problem.
- Alpha and Beta are especially frequent in Mediterranean countries, Africa, the Middle East, South-East Asia, and the Indian subcontinent but also because of the migration of the last years often seen in Western-Europe.
- Due to demographic changes during the last decades their incidence has increased worldwide.
- Up-to-date, no ultimate cure apart from bone marrow transplantation is available.
- Therefore, Health Authorities focus on screening programs.
People with Thalassemia disease are not able to make enough hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of the body. When there is not enough hemoglobin in the red blood cells, oxygen cannot get to all parts of the body. Organs then become starved for oxygen and are unable to function properly.
There are two primary types of Thalassemia disease, Alpha Thalassemia disease and Beta Thalassemia disease. Beta Major (also known as Cooley’s Anemia) is a serious illness. Symptoms appear in the first two years of life and include paleness of the skin, poor appetite, irritability, and failure to grow. Proper treatment includes routine blood transfusions and other therapies.
The ViennaLab Thalassemia PCR StripAssay ®
• are based on reverse-hybridization of biotinylated PCR products
• combine probes for mutations and controls in a parallel array of allele-specific oligonucleotides
• work with immobilized oligos on a teststrip
• show mutations by enzymatic color reaction easily visible to the naked eye
• Click here to go to the ViennaLab video explaining the technologie
Application Note: Validation of a reverse-hybridization StripAssay for the simultaneous analysis of common a-thalassemia point mutations and deletions.
|Beta-Globin Stripassay® MED||4-130||20 Tests||Detection of 22 mutations covering >90% of Beta-Globin defects found in Mediterranean countries|
|Beta-Globin Stripassay® IME||4-140||20 Tests||Detection of 22 mutations covering >90% of Beta-Globin defects found in the Middle East and India|
|Beta-Globin Stripassay® SEA||4-150||20 Tests||Detection of 22 mutations covering >90% of Beta-Globin defects found in Southeast Asia|
|Alpha-Globin Stripassay®||4-160||10 Tests||Detection of 21 common Alpha-Globin gene mutations|
|Beta-Thalassemia Modifier StripAssay®||4-170||20 Tests||Testing for 5 polymorphisms associated with severity of Beta-Thalassemia|