This product detects bordetella pertussis and bordetella parapertussis in one reaction. During detection, amplification of the insertion sequences IS1002, for both bordetella pertussis and parapertussis, and IS1001, only for bordetella parapertussis, is found. Bordetella pertussis presence is indicated by the FAM fluorophore fluorescence growth and at the same time by the absence of fluorescence in the Cy5 channel. Bordetella parapertussis presence is indicated by the fluorescence growth in FAM and Cy5 channelsDiagnosis of the bacterium should take place within the first three weeks of infection. After three weeks, the bacterium is no longer detectable in the nasopharynx. For detection by means of PCR, a smear is often taken from the nasopharynx.
Bordetella pertussis and bordetella parapertussis are two bacteria that produce different toxins that cause whooping cough. Both bordetella pertussis and parapertussis attach to the ciliated epithelium of the respiratory tract where multiple locally acting toxins are produced. The production of these toxins causes necrotizing tissue damage, which leads to whooping cough. The associated symptoms appear after 7 to 10 days after contact with the bacteria.
Whooping caugh can cause serious complications, especially in unvaccinated babies whose mothers have not been vaccinated. complications that can arise in such a situation are pneumonia, encephalopathy a disease of the brain), seizures and even death. In adults, complications that can occur include short-term inability to breathe, broken ribs, rectal prolapse, and hernias.
COMPATIBLE WITH A WIDE RANGE OF REAL-TIME PCR DEVICES
CE IVD CERTIFIED DIAGNOSTIC TEST