The CYP2C9 mpx Realfast Assay

The CYP2C9 mpx RealFast Assay is a fast and accurate multiplex real-time PCR test
for the simultaneous detection of the
c.430C>T (CYP2C9*2) and c.1075A>C (CYP2C9*3) polymorphisms in the human CYP2C9 gene.

Both variants of the CYP2C9 enzyme, *2 (c.430C>T) and *3 (c.1075A>C), exhibit impaired function leading to poor metabolism (PM) phenotypes for various drugs. Individuals with PM phenotype (i.e. genotypes with homozygous or compound heterozygous *2 or *3 alleles) are at greater risk of severe bleeding during coumarin-based anticoagulation therapy with warfarin, acenocoumarol and phenprocoumon.

SPECIFICATIONS

  • CE-IVD
  • Highly specific NG detection 
  • Two variants (184 bp and 140 bp fragment)
  • Sensitivity 100%/ Specificity 100%
  • Easy setting up and analyzing on different types of instruments with Viennalab software

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