Cytochrome P450 genes, also known as CYP genes, are a group of genes that play an important role in the breaking down of various medications. The enzymes regulated and expressed by these genes are mainly active in the liver. These enzymes ensure that edogenous lipophilic substances and exogenous substances are excreted via urine. The human genome contains 57 CYP genes that are known to date. An important function of the CYP genes is the involvement in drug metabolism, expecially regularly prescribed drugs. Therefore, genotyping of these genes can be very important to gain knowledge for the optimal medication for each patient. Viennalab has made a video where the principle of the test is explained. Click here for this video.
For more information about certain drug-gene interactions, click on the button on the right. Viennalab uses strip assays and a realfast PCR assay to help you with your CYP genotyping.
Both variants of the CYP2C9 enzyme, *2 (c.430C>T) and *3 (c.1075A>C), exhibit impaired function leading to poor metabolism (PM) phenotypes for various drugs. Individuals with PM phenotype (i.e. genotypes with homozygous or compound heterozygous *2 or *3 alleles) are at greater risk of severe bleeding during coumarin-based anticoagulation therapy with warfarin, acenocoumarol and phenprocoumon. Do you want more info about this Assay click here.
The ViennaLab PGX-CYP2D6 XL StripAssay® in combination with the CYP2D6 RealFastTM CNV Assay identifies patients with an altered CYP2D6 enzyme function. Comprehensive CYP2D6 genotyping optimizes the choice of medication and/or the adjustment of drug dosage and consequently reduces the risk of adverse events or lowered treatment efficacy. This realfast CNV Assay detects Gen deletion and gen duplication very easy, fast and accurate. Do you want more info about this Assay click here.
Variations in the CYP2C19 gene lead to inappropriate concentrations of drugs or drug metabolites in the body, which may lead to toxicity, risk of adverse drug reactions or impaired drug efficacy. The PGX-CYP2C19 StripAssay® detects genetic variants resulting in reduced or increased activity of the cytochrome P450 isoenzyme CYP2C19. This assay detects CYP2C19 variants *2, *3, *4, *5, *6, *7, *8, and *17. Do you want more info about this Assay click here.
Differences in the activity of the liver enzyme CYP2D6 contribute to the inter-individual variability in a majority of drug responses. An assay for the identification of CYP2D6 variants *3, *4, and *6 based on polymerase chain reaction (PCR) and reverse-hybridization. Do you want more info about this Assay click here.
The Viennalab strip assays work ideally with the DYNABLOT heat. Up to 30 strip assays can be run simultaneously in the DYNABLOT. Due to this combination, 120 strip assays can be performed per day in a fully automated manner.
DYNABLOT Heat is a small, compact, and stand-alone instrument for the automatic processing of hybridization tests. It offers precise temperature control within the range of 35 – 65 °C during the process with regard to accuracy, stability, and uniformity.
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After completion, Goffin Molecular Technologies will contact you as soon as possible.