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Aspergillus could cause a type of fungal infection that predominantly affects the respiratory system. This ubiquitous mold can cause various conditions, from allergic reactions to severe lung infections, especially in immunocompromised individuals. Respiratory manifestations may include aspergillosis and invasive pulmonary aspergillosis, both requiring prompt and accurate diagnosis. Diagnostic tools often involve culture tests, histopathological examination, and advanced molecular methods like PCR. Timely identification and treatment are crucial, particularly for high-risk patients, to improve outcomes and minimize complications.