EGFR-Multiplex 0.1% AF cfDNA
EGFR-Multiplex 0.1% AF cfDNA is a reference material for the validation of EGFR mutation testing in liquid biopsy. It contains a mix of TKI-sensitive and TKI-resistant EGFR mutations at an allele frequency of 0.1 per cent, in highly characterised human cell-free DNA derived from cell lines. The material is used as a standard in liquid biopsy assays and in the development and validation of EGFR test kits. Unit size 400 ng, ready to use.
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This kit in detail
- Mix of TKI-sensitive and TKI-resistant EGFR mutations
- Allele frequency 0.1 per cent
- Human cell-free DNA from characterised cell lines
- For liquid biopsy assays and for validating EGFR test kits
- Unit size 400 ng, ready to use
EGFR-Multiplex 0.1% AF cfDNA is a reference material for EGFR mutation testing on cell-free DNA. EGFR mutations determine the choice of treatment in non-small cell lung cancer, where the distinction between mutations that respond to tyrosine kinase inhibitors and mutations that confer resistance to them is decisive.
Composition
The material contains a mix of TKI-sensitive and TKI-resistant EGFR mutations at an allele frequency of 0.1 per cent. The cell-free DNA is of human origin and derived from characterised cell lines, so the mutation content and the allele frequency are known.
Applications
The material serves as a standard in liquid biopsy assays in diagnostic and R&D laboratories, and in the validation and development of EGFR test kits. Liquid biopsy provides tumour genotype information without a tissue biopsy, which places demands on the sensitivity of the assay; a reference material at a known allele frequency is what makes that sensitivity measurable.
Format
The unit size is 400 ng and the material is supplied ready to use.
- EGFR-Multiplex 0.1% AF cfDNA
This product is ready to use.
Datasheets and regulatory documentation
Everything your quality team needs for evaluation and procurement.
Instruction for Use
Frequently paired with this kit
Other assays and instruments lab teams add alongside the EGFR-Multiplex 0.1% AF cfDNA.
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