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The OncoKit Revolution: Pinpointing p.D816V in Systemic Mastocytosis
The p.D816V OncoKit is a transformative tool, designed to provide critical insights into the challenging landscape of Systemic Mastocytosis (SM), a rare hematological disorder. Utilizing advanced digital PCR (dPCR) technology, the kit offers an invaluable resource for healthcare technicians and molecular biology professionals.
Systemic Mastocytosis is a condition characterized by the abnormal proliferation and accumulation of mast cells in various tissues, including the skin, bone marrow, and other extracutaneous tissues. The disorder can manifest in a range of subtypes. It’s crucial to note that a staggering 90% or more of SM patients exhibit the p.D816V mutation, which has significant implications for both diagnosis and treatment strategies.
The KIT gene plays a pivotal role in encoding a protein essential for cellular proliferation. The p.D816V mutation presents a unique challenge as it disrupts the natural cellular equilibrium. This alteration leads to ligand-independent activation, causing an escalation in cellular proliferation while diminishing apoptosis rates. Importantly, this specific mutation shows resistance to certain tyrosine kinase inhibitors, underlining the critical need for its accurate detection to inform therapeutic decisions.
Why Opt for the p.D816V OncoKit
Unmatched Precision and Accuracy: Employs cutting-edge digital PCR technology for precise and accurate quantification of mutated and wild-type alleles.
User-Friendly Design: The kit has been thoughtfully designed to include all essential components, ensuring a hassle-free and efficient workflow for users.
Solid Validation Credentials: Backed by rigorous validation against synthetic DNA that includes both mutated and wild-type alleles, guaranteeing both reliability and consistency.
Exceptional Sensitivity: Features outstanding limits for both detection and quantification, thereby enabling the discovery of low-frequency mutation occurrences.
Broad Compatibility: Fully optimized for compatibility with leading PCR systems like QuantStudio™ Absolute Q™, offering a smooth transition into your existing lab infrastructure.
Elevate Your Research: Why OncoKit is the Go-To Resource
Navigating the complexities of hematological disorders like Systemic Mastocytosis requires robust, reliable, and precise tools that can adapt to the evolving landscape of medical research. The p.D816V OncoKit is precisely engineered to meet these needs. Offering a suite of exceptional features such as digital PCR technology, precise p.D816V mutation quantification, and seamless compatibility with advanced lab systems, the OncoKit sets a new standard in the field. For healthcare and molecular biology professionals committed to advancing their research in this critical area, the p.D816V OncoKit serves as an invaluable, rigorously validated resource that stands as a dependable cornerstone in any advanced laboratory setting.
The kit is equipped with reagents for 24 reactions, including: