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The Factor XIII genetic predisposition relates to a blood clotting protein essential for hemostasis, the process that prevents excessive bleeding. Factor XIII is activated by thrombin in the final stage of the coagulation cascade, cross-linking fibrin to stabilize blood clots. Deficiency or abnormal functioning of Factor XIII can result in bleeding disorders, delayed wound healing, and an increased risk of miscarriage in women. Variants in the Factor XIII gene can also have implications for cardiovascular diseases, as a properly functioning Factor XIII is essential for maintaining vascular integrity. Knowledge of one’s Factor XIII status is valuable for diagnostic, prophylactic, and therapeutic decision-making.