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Factor II

Factor II Prothrombin, also known as Factor II G20210A or the Factor II mutation, is a common genetic disorder that affects blood clotting. It is a type of thrombophilia, a condition characterized by an increased tendency to form blood clots within the blood vessels. This condition is associated with a mutation in the gene responsible for the production of prothrombin, a key protein involved in the blood clotting process.

The Genetic Basis of Factor II Prothrombin

Factor II Prothrombin is caused by a specific point mutation in the gene that encodes for prothrombin, also known as Factor II. The mutation results in a single nucleotide change in the gene’s DNA sequence at position 20210, from guanine (G) to adenine (A). As a result of this mutation, the production of prothrombin is increased, leading to elevated levels of this clotting protein in the blood. This excessive prothrombin can cause an imbalance in the body’s clotting mechanism, promoting the formation of blood clots more easily than in individuals without the mutation.

Inheritance and Prevalence

Factor II Thrombin is inherited in an autosomal dominant pattern, which means that only one copy of the mutated gene from either parent is sufficient to cause the condition. If an individual inherits one copy of the mutated gene (heterozygous), their risk of developing blood clots is increased but not as significantly as individuals who inherit two copies (homozygous). Homozygous individuals have a higher risk of clotting complications.

Factor II Prothrombin is one of the most common genetic risk factors for thrombosis, particularly among individuals of European ancestry. It is estimated that around 3-8% of the Caucasian population carries at least one copy of the mutation.


Diagnosing Factor II Prothrombin involves a series of blood tests to detect the presence of the mutation. The most common test is the Factor II DNA test, which identifies the specific genetic change associated with this disorder. Doctors may also conduct other tests, such as a D-dimer test to measure the presence of a protein fragment released during clot breakdown and imaging scans like ultrasound or venography to detect existing blood clots.


Factor II Prothrombin is a prevalent genetic disorder affecting the blood clotting process. While many carriers of this mutation may never experience any complications, it is essential to be aware of its potential risks and take preventive measures, especially in high-risk situations. If you have a family history of blood clotting disorders or experience any unexplained clotting incidents, it is crucial to consult with a healthcare professional and undergo appropriate testing for Factor II Leiden and other thrombophilias. Early detection and proper management can significantly reduce the risk of serious complications associated with this genetic condition.

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