Hepatitis B

Hepatitis B Virus (HBV) has a partially double-stranded DNA genome with four overlapping open reading frames (ORFs):

• Pol: Codes for the viral DNA polymerase and has reverse transcriptase activity.
• S: Produces the surface antigen (HBsAg), critical for viral encapsulation and immune response.
• C: Produces the core antigen (HBcAg) and e antigen (HBeAg), which are essential for viral assembly and modulation of host immune response.
• X: Codes for the HBx protein, involved in transcriptional activation and thought to be linked to hepatocellular carcinoma.

Some key markers for diagnosis include:

• HBsAg (Hepatitis B surface antigen): Indicates an active infection.
• Anti-HBs: Signifies immunity, either through vaccination or previous infection.
• Anti-HBc: Denotes current or past infection.
• HBeAg: Suggests that the virus is actively replicating and that the infected person is highly contagious.

This understanding of the molecular characteristics of Hepatitis B is crucial for developing precise diagnostics, treatment protocols, and preventive measures, making it a fundamental subject for labs engaged in hepatology research.

When you’re looking for reliable diagnostic solution for Hepatitis B, the GeneProof Hepatitis B Virus (HBV) PCR Kit stand as a strong option.