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PAI-1 (Plasminogen Activator Inhibitor-1) is a key genetic marker associated with increased risk of thrombosis and cardiovascular disease. Elevated levels of PAI-1 inhibit the breakdown of blood clots, making individuals with high PAI-1 more susceptible to conditions like deep vein thrombosis, stroke, and heart attacks. The PAI-1 gene can be influenced by various factors including diet, lifestyle, and medications, but there is also a genetic component that contributes to its elevated levels. Genetic testing can identify those at higher risk, enabling proactive management through lifestyle changes and possibly anticoagulant medications. Early detection and management are essential for reducing cardiovascular risk.