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Mastocytosis is a rare disorder characterized by the excessive accumulation of mast cells in tissues such as the skin, bone marrow, and internal organs. These cells play a vital role in immune responses but can cause problems when present in high numbers. Symptoms often include skin lesions, allergic reactions, and, in severe cases, anaphylaxis. The condition can manifest in various forms, including cutaneous mastocytosis, primarily affecting the skin, and systemic mastocytosis, impacting multiple bodily systems. Diagnosis typically involves skin tests, blood tests, and bone marrow biopsies. Treatment focuses on controlling symptoms and may include antihistamines, mast cell stabilizers, and sometimes chemotherapy for severe cases.