Pharmacogenomics (PGx) is a scientific discipline that focuses on understanding how an individual’s genes affect their response to drugs. It has been instrumental in advancing personalized medicine, providing insight into how specific genetic variants can influence drug metabolism, efficacy, and toxicity. Recently, there has been a surge of interest in leveraging PGx for disease detection, including Human Immunodeficiency Virus (HIV). This article explores the potential implications and challenges of applying PGx for HIV testing.