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α-Globin StripAssay kit

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The α-Globin StripAssay kit from Viennalab is a highly reliable and efficient tool for detecting deletions and mutations in the α-globin gene cluster, which is important for the diagnosis of thalassemia and related disorders. The kit utilizes a simple and easy-to-use strip-based assay that allows for the simultaneous detection of up to 11 different mutations or deletions in the α-globin gene cluster.

The kit is designed to provide accurate results with high sensitivity and specificity, and is compatible with a variety of sample types, including whole blood, dried blood spots, and genomic DNA. Its fast and efficient workflow, combined with its high accuracy and reliability, make it an ideal tool for use in clinical diagnostic laboratories, research settings, and other applications where rapid and accurate detection of α-globin gene mutations is needed.

Product highlights

  • Reliable and efficient method
  • Simple workflow
  • Includes all necessary components
  • Simultaneous detection of multiple mutations
  • High sensitivity and specificity

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α-Globin StripAssay kit

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Specifications of the α-Globin StripAssay kit

The α-Globin StripAssay kit from Viennalab is a diagnostic tool for detecting genetic mutations in the alpha-globin gene cluster. This kit is designed to be used by laboratory professionals and scientists who work in the field of molecular diagnostics, specifically in the area of hematology.

The alpha-globin gene cluster is located on chromosome 16 and is composed of four functional genes: two alpha-globin genes (HBA1 and HBA2) and two embryonic alpha-like genes (HBZ and HBM). The alpha-globin genes are responsible for producing alpha-globin chains, which combine with beta-globin chains to form hemoglobin, the protein that carries oxygen in red blood cells.

Mutations in the alpha-globin genes can result in a variety of disorders, including alpha-thalassemia, a group of inherited blood disorders that are characterized by reduced or absent production of alpha-globin chains. Alpha-thalassemia can range in severity from asymptomatic to life-threatening, depending on the number and type of mutations present.

The α-Globin StripAssay kit from Viennalab is a PCR-based assay that allows for the detection of common mutations in the alpha-globin gene cluster. The kit contains all of the necessary reagents and controls for performing the assay, including PCR primers and probes that are specific for the targeted mutations. The assay is designed to be run on standard PCR equipment and can be completed in less than 4 hours.

One of the key benefits of the α-Globin StripAssay kit is its ability to detect multiple mutations in a single reaction. The kit targets 20 different mutations in the alpha-globin gene cluster, allowing for comprehensive screening of patients with suspected alpha-thalassemia. In addition, the kit includes controls to ensure the accuracy and reproducibility of the results.

Another advantage of the α-Globin StripAssay kit is its ease of use. The kit is designed to be user-friendly, with clear instructions and an intuitive workflow. This makes it suitable for use in both high- and low-throughput laboratories.

Overall, the α-Globin StripAssay kit from Viennalab is a valuable tool for laboratory professionals and scientists who are involved in the diagnosis of hemoglobinopathies. Its ability to detect multiple mutations in a single reaction, combined with its ease of use and comprehensive controls, make it a reliable and efficient diagnostic tool for the detection of alpha-thalassemia.

Components of the α-Globin StripAssay kit
  1. StripAssay test strips (12-well format)
  2. DNA extraction buffer
  3. Positive and negative controls
  4. StripAssay hybridization buffer
  5. StripAssay detection reagent
  6. StripAssay stop reagent
  7. Instruction manual

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