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Imegen-SCAs: Unlocking the Genetic Secrets of Cerebellar Ataxia
Cerebellar ataxias are a group of neurodegenerative disorders characterized by progressive problems with coordination and balance. These conditions can severely impact a person’s quality of life, making early and accurate diagnosis crucial. Imegen-SCAs is a cutting-edge diagnostic kit designed to detect expansions associated with various cerebellar ataxias, including SCA1, SCA2, SCA3, SCA6, SCA7, SCA12, SCA17, and DRPLA.
Comprehensive Expansion Analysis
Imegen-SCAs employs advanced fragment analysis technology to provide a comprehensive assessment of triplet repeat expansions linked to cerebellar ataxias. The kit is capable of detecting expansions in the range of 100 to 500 base pairs, offering a detailed view of the genetic anomalies associated with these conditions.
TP-PCR for Enhanced Detection
In addition to conventional PCR-based analysis, Imegen-SCAs features a Triple Repeat Primed PCR (TP-PCR) system. This innovative technology is specifically designed to identify expansions in SCA2 and SCA7 that may go undetected by conventional methods. By using TP-PCR, clinicians can achieve a more accurate diagnosis, resulting in better patient care.
Quality and Compliance
Imegen-SCAs meets the highest standards of quality and compliance. It adheres to the requirements outlined in ISO 13485 and ISO 14001, ensuring the reliability of results. The kit includes a positive control with normal alleles for all assays, demonstrating the functionality of the prepared amplification reactions.
Simple Workflow, Invaluable Insights
The Imegen-SCAs kit offers a streamlined workflow, with a manual work time of just 45 minutes. The PCR/TP-PCR program takes only 2 hours and 30 minutes to complete. This efficiency is crucial for busy laboratories and healthcare professionals who need quick and reliable results.
Imegen-SCAs is designed to work seamlessly with a wide range of conventional thermal cyclers. Its compatibility with standard laboratory equipment ensures accessibility for labs around the world.
Invaluable Information for Differential Diagnosis
The results provided by Imegen-SCAs enable clinicians to establish a phenotype-genotype correlation. This information is invaluable for differential diagnosis, predicting disease progression, monitoring symptoms, and providing essential genetic counseling to affected individuals and their families.
In Vitro Diagnostic Use
Imegen-SCAs is intended for in vitro diagnostic use only and is suitable for professionals in the molecular biology sector. It empowers healthcare providers with the genetic insights needed to make informed decisions and provide the best possible care for individuals with cerebellar ataxias.
In the quest to unravel the mysteries of cerebellar ataxias, Imegen-SCAs stands as a powerful tool, bringing us one step closer to earlier diagnoses, improved patient care, and a deeper understanding of these complex neurodegenerative disorders.
Ataxia A Master Mix, Ataxia B Master Mix, General Master Mix III, General Master Mix IV, SCAs Master Mix, Positive Control