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Exploring the HLA-B Gene Kit
In the world of molecular diagnostics, precision and efficiency are paramount. The HLA-B Gene Kit stands as a testament to these principles, offering a comprehensive solution for the precise detection of the HLA-B27 allele. This groundbreaking kit is designed to cater to the needs of professionals in the molecular biology sector, providing them with a powerful tool for genetic investigations.
Nestled within the major histocompatibility complex (MHC) region on chromosome 6p21, the HLA-B27 allele plays a pivotal role in our immune system’s ability to recognize and respond to foreign invaders. This kit is specifically tailored to detect the HLA-B27 allele, a gene with numerous variations and subtypes. Importantly, these genetic variants are closely associated with autoimmune inflammatory diseases of the spine, such as Ankylosing Spondylitis (AS). Additionally, the presence of HLA-B27 has been linked to favorable outcomes in HIV and hepatitis C virus (HCV) infections.
This kit utilizes a qualitative real-time PCR assay to detect the HLA-B*27 allele with unmatched precision. It’s crucial to clarify that this kit is not intended for histocompatibility testing prior to transplantation. Instead, it serves as a powerful screening method for autoimmune inflammatory diseases of the spine, rachis, and sacroiliac joints, enabling early diagnosis and intervention.
Unique Features of the HLA-B Gene Kit
Precision Perfected: Our kit features a meticulously designed molecular approach that homes in on specific polymorphisms within exon 2 of the HLA-B gene. This results in unmatched precision and specificity when detecting the HLA-B27 allele.
Validation for Reliability: Rigorous validation processes involving diagnostic reference materials from esteemed institutions, including the Coriell Institute for Medical Research and C.H.U. Insular Materno-Infantil, have affirmed the reliability and accuracy of our diagnostic method.
Quality Control In-Built: Included in the kit is an endogenous gene, β-globin, which serves as a built-in positive control. This control not only ensures the DNA sample’s quality but also strengthens the integrity of the entire testing process.
Sample Simplicity: Utilizing the HLA-B Gene Kit is hassle-free, as it requires just 50 ng of genomic DNA, typically obtained from peripheral blood or saliva, for accurate analysis.
Certified Excellence: Developed by Health in Code S.L., the kit adheres to the highest industry standards, holding certifications under UNE-EN ISO 13485:2018 and ISO 14001. This underscores the quality maintained throughout the manufacturing process.
Multiplex Advancement: Our kit goes a step further by allowing the amplification of various subtypes of the B27 allele, all located in exon 2 of the HLA-B gene. This multiplex approach enhances sensitivity and specificity in detection.
The Future with the HLA-B Kit
In the ever-evolving landscape of molecular diagnostics, tools like the HLA-B Gene Kit are beacons of progress. This innovative product isn’t just a technological marvel; it represents the future of precise and efficient laboratory operations.
For molecular biology professionals seeking the right tools for genetic investigations, understanding the merits of this kit is paramount. It combines precision, efficiency, and compliance, delivering results that modern labs demand.
In the grand mosaic of scientific equipment, the HLA-B Gene Kit shines as a testament to the strides made in laboratory science and the promising directions it’s taking. Choose the HLA-B Gene Kit for unwavering diagnostic excellence. Contact us today to explore how this kit can enhance your diagnostic capabilities and contribute to improved patient care.
The kit contents the necessary reagents to perform 48 reactions. The reagents included in the kit are the following: