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HLA-B5701 PCR Kit

Short description

The Viennalab HLA-B5701 RealFast™ Assay is a reliable and efficient way to prevent hypersensitivity reactions to abacavir in HIV-infected patients.

Abacavir is commonly used in combination therapy for the treatment of HIV, but the HLA-B57:01 allele is strongly associated with abacavir hypersensitivity, and HLA-B57:01 positive patients must be excluded from such treatment. Screening patients for the presence of HLA-B57:01 before starting abacavir therapy can significantly reduce the incidence of hypersensitivity reactions. The Viennalab assay accurately determines the presence or absence of HLA-B57:01 alleles, providing a crucial tool for preventing adverse reactions.

Product highlights

  • Abacavir is used for the treatment of HIV patients
  • The HLA-B*57:01 allele is a variant of the HLA-B gene
  • Screening of patients for the presence of HLA-B*57:01

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HLA-B5701 PCR Kit

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Instructions for Use

 

Specifications of the HLA-B5701 PCR Kit

Looking for a reliable and efficient way to prevent hypersensitivity reactions to abacavir in your HIV-infected patients? Look no further than the Viennalab HLA-B5701 RealFast™ Assay! Our assay accurately determines the presence or absence of HLA-B*57:01 alleles, providing a crucial tool for preventing adverse reactions.

Abacavir is a commonly used antiretroviral drug in combination therapy for the treatment of HIV-infected patients. However, the HLA-B57:01 allele, a variant of the human leukocyte antigen B (HLA-B) gene, is strongly associated with abacavir hypersensitivity. HLA-B57:01 positive patients must be excluded from such treatment. Screening patients for the presence of HLA-B*57:01 before starting abacavir therapy can significantly reduce the incidence of hypersensitivity reactions (HSR).

Trust in the Viennalab HLA-B5701 RealFast™ Assay to provide you with accurate and reliable results, enabling you to make informed treatment decisions for your patients. Order now and experience the convenience and efficiency of RealFast™ technology!

Components of the HLA-B5701 PCR Kit
  1. DNA Extraction Kit: A kit containing all the reagents necessary for the extraction of genomic DNA from a blood or saliva sample, including DNA extraction buffer, proteinase K, and magnetic beads.
  2. PCR Mix: A ready-to-use mix containing all the reagents necessary for the PCR amplification of the HLA-B gene region of interest.
  3. HLA-B5701 Primer Mix: A mix of primers specific for the HLA-B*5701 allele.
  4. Probe Mix: A mix of probes specific for the detection of the HLA-B*5701 allele.
  5. Control DNA: A synthetic DNA that is added to the sample as an internal control to ensure that the assay is working correctly.
  6. DNase/RNase-free Water: Water that has been treated to remove contaminating DNases and RNases, which can degrade the extracted DNA.

 

The kit also includes instructions for use, as well as a protocol for the detection of the HLA-B*5701 allele using real-time PCR.

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