PGX-5FU StripAssay

5-FU is rapidly metabolized in the liver, 5FUwith dihydropyrimidine dehydrogenase (DPD) being the rate-limiting enzyme. 5-Fluorouracil (5-FU) is widely and successfully used for the treatment of solid tumors. In some patients, however, an enzyme variant results in the need of therapy adjustment. The majority of the 3 to 5% of patients not adequately metabolizing 5-fluorouracil (5-FU) carry a specific mutation in their DPYD gene. While heterozygous patients should be given lower 5-FU doses, homozygous patients should receive alternative chemotherapeutic treatment. Identification of the relevant mutation in DPD and determination of whether a carrier is homozygous or heterozygous for this DPD mutation is crucial for allowing an adequate 5-FU therapy. 5FU StripAssay

The PGX-5FU StripAssay identifies the most common mutation with therapeutic relevance for 5-FU treatment.

The ViennaLab PGX-5FU StripAssays®
• are based on reverse-hybridization of biotinylated PCR products
• combine probes for mutations and controls in a parallel array of allele-specific oligonucleotides
• work with immobilized oligos on a teststrip
• show mutations by enzymatic color reaction easily visible to the naked eye

StripAssay®GeneSNPFCGR 5-670
PGX-5FU 4-720
FCGRFCGRIIAH131Rx
FCGRIIAF158Vx
PGX-5FUDPYDIVS14+1 G>Ax

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Total Overview All Viennalab StripAssays