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Fc Gamma Receptors (FCGR) are receptors which are important for the immune system involved in processes like phagocytosis and antibody-dependent cell-mediated cytotoxicity. Variations or mutations in FCGR genes can significantly influence the efficacy of antibody-based treatments for various conditions, including cancers and autoimmune disorders. Understanding an individual’s FCGR genetic profile can help tailor treatment plans that are more effective and less prone to adverse reactions. It can be particularly important in determining the response to monoclonal antibody therapies, thereby influencing clinical outcomes and improving patient care.