Infective endocarditis is a complex and potentially life-threatening infection that affects the heart’s endocardium and valves. Early diagnosis and prompt treatment are essential for reducing morbidity and mortality associated with this condition. Prevention measures, careful patient evaluation, and antibiotic prophylaxis in select cases remain crucial in managing IE, particularly in individuals with underlying cardiac conditions or other risk factors. Understanding the epidemiology, etiology, and pathophysiology of IE is critical for healthcare professionals to provide optimal care for affected patients.