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Hemochromatosis PCR Kit – The Game-Changer in Iron Management
Iron management in the body is a critical factor for overall health. Any imbalance in iron metabolism can lead to conditions like Hemochromatosis. That’s where our Hemochromatosis PCR kit comes into play. Engineered for in-vitro diagnostic use, this qualitative real-time PCR analysis kit is designed to detect mutations in the HFE gene responsible for iron absorption and kinetics.
Pinpoint Precision: What Sets Us Apart
The kit leverages a combination of oligonucleotides and fluorescent hydrolysis probes to identify variants in the HFE gene with unmatched precision. Specifically, the kit can detect the following alleles:
– HFE63 [NM_000410.3:c.187C>G (p.His63Asp)]
– HFE65 [NM_000410.3:c.193A>T (p.Ser65Cys)]
– HFE282 [NM_000410.3:c.845G>A (p.Cys282Tyr)]
A Three-in-One Solution: Multiplex Real-Time Analysis
Performing three multiplexed real-time PCR reactions, the kit enables the simultaneous amplification of both reference and alternative genotypes, providing comprehensive data in a single analysis.
The Trust Factor: Our Certifications
Our kit is certified according to UNE-EN ISO 13485:2018 standards and has been validated using medical genetic samples from Health in Code S.L., Coriell Institute reference samples, and synthetic DNA, ensuring utmost reliability.
Your Sample Guide: Requirements and Specifications
– Type of Sample: Genomic DNA from peripheral blood.
– Recommended Quantity: 150 ng of DNA.
In Tune with Technology: Fluorescence Channels
Compatible with FAM™ and VIC™ fluorescence channels, the kit is versatile and adaptable to various lab settings.
Behind the Science: The Kit’s Mechanism
The HFE gene, responsible for iron regulation through hormone hepcidin, is often mutated in Hemochromatosis patients, causing iron overload. These mutations prevent the HFE protein from interacting with hepcidin, leading to iron accumulation and subsequent organ damage. Our kit identifies these mutations, enabling professionals in the molecular biology sector to diagnose and manage Hemochromatosis efficiently.
Going Green: Our Eco-Friendly Promise
Providing not just a product but a solution, the Hemochromatosis PCR Kit is an investment in effective diagnosis and management. The kit is packaged using materials containing 30-100% recycled content, aligning with our commitment to sustainability.
The Last Word: Why This Kit is Essential
Time, reliability, and accuracy are of the essence in laboratory diagnostics. The Hemochromatosis PCR Kit empowers you to make data-driven decisions swiftly and confidently, offering a critical tool in the early detection and management of iron-related disorders.
Elevate your lab’s capabilities—choose the Hemochromatosis PCR Kit for precise, reliable, and sustainable diagnostics.
The kit contents the necessary reagents to perform 48 reactions. The reagents included in the kit are the following: