Factor V Leiden

The Genetic Basis of Factor V Leiden

Factor V Leiden is caused by a mutation in the Factor V gene, leading to a change in the protein’s structure. The mutation results in an alteration of the Factor V protein, making it resistant to being inactivated by a natural anticoagulant called activated protein C (APC). As a result, the mutated Factor V remains active in the clotting process for a longer time, increasing the risk of blood clot formation.