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Factor XII and the Importance of the FXII 46C>T RealFast Assay
Factor XII, also known as the Hageman factor, is integral in the intrinsic pathway of the coagulation cascade. The FXII 46C>T RealFast Assay from Viennalab swiftly and accurately detects the 46C>T mutation in the Factor XII (F12) gene. Homozygosity for the T allele may indicate an elevated risk for venous thrombosis.
– The assay kit discerns between the three potential FXII 46C>T genotypes.
### **H1: Factor XII (Hageman Factor): A Brief Introduction**
**H2: The Vital Role of Factor XII in Coagulation**
**H2: Implications of Factor XII Deficiency**
Deficiency or irregularities in Factor XII have been notably associated with thromboembolic complications. Some of these potentially life-threatening complications include:
– Venous and arterial thrombosis
– Ischemic stroke
– Coronary heart disease
Understanding the genetic background of patients can be essential in assessing their risk profile for these conditions.
### **H1: The FXII 46C>T RealFastTM Assay: Detection, Accuracy, and Application**
**H2: Detecting the 46C>T Mutation with Precision**
The FXII 46C>T RealFastTM Assay stands as a cutting-edge real-time PCR test tailor-made to identify the 46C>T mutation in the F12 gene. Recognizing patients with the TT genotype, who potentially have heightened susceptibility to thrombotic disorders, becomes seamless and efficient with this test.
**H2: Genotypic Discrimination with the FXII 46C>T RealFastTM Assay**
This qualitative assay is proficient in discriminating between the three possible FXII 46C>T genotypes from a human DNA extract. These genotypes are:
– CC (standard)
– CT (heterozygous)
– TT (homozygous mutant)
### **H1: Advantages of the FXII 46C>T RealFastTM Assay**
– **Quick and Efficient:** The “RealFast” in its name isn’t for show. This assay offers rapid and accurate results.
– **Precision:** Discriminates between all three potential FXII 46C>T genotypes.
– **Clinical Significance:** Identifying the TT genotype can be crucial in gauging the risk for venous thrombosis and other related complications.
– **Reference Accuracy:** With reference sequences like HGVS: NG_007568.1:g.5046T>C and NCBI dbSNP: rs1801020, the assay ensures top-notch reliability.
In the dynamic world of lab sciences, being equipped with the right tools is paramount. The FXII 46C>T RealFastTM Assay emerges as a quintessential instrument for any lab scientist delving into the intricacies of the Factor XII gene and its implications in thrombotic disorders.