Introducing Imegen® Huntington Disease Kit for In Vitro Diagnostic Use:

Product Overview: Imegen® Huntington Disease Kit allows semi-quantitative analysis of CAG expansion in the HTT gene via HTT-C and HTT-L PCR assays. It covers a 100-500 bp amplification range, featuring a positive control with normal alleles. Validated with related neurodegenerative disease products, it complies with ISO 13485 and ISO 14001 quality standards.

Key Features:

• Semi-Quantitative CAG Analysis
• Dual PCR Assays (HTT-C and HTT-L)
• 100-500 bp Amplification
• Included Positive Control
• Compatible with Neurodegenerative Disease Assays
• In Vitro Diagnostic
• 50 ng DNA per Reaction
• Peripheral Blood Samples
• 2 Reactions per Sample
• Targets: CAG and poly-CCG
• Quick Setup (45 mins)
• PCR Program (2h 15 mins)
• Compatible with Standard Cyclers
• 6-FAM and NEDTM Sequencing

About Huntington’s Disease: Huntington’s Disease is an inherited neurodegenerative disorder causing progressive brain neuron degeneration, impacting motor skills, cognition, and mental health. Diagnosis hinges on CAG triplet repeat analysis, with <26 repeats as normal, 27-35 intermediate, and >36 as pathological.

Imegen® Huntington Kit offers precise CAG expansion analysis with HTT-C (short-range) and HTT-L (long-range) PCR, covering polymorphic poly-CCG fragments. Sequencing via 6-FAM and NEDTM-labeled PCR products separates amplicons for size analysis.

References:

• Potter NT, Spector EB, Prior TW. Technical standards and guidelines for Huntington disease testing. Genet Med. 2004 Jan-Feb;6(1):61-5.
• Losekoot M et al. EMQN/CMGS best practice guidelines for the molecular genetic testing of Huntington disease. Eur J Hum Genet. 2013 May;21(5):480-6.

Imegen® Huntington Kit is designed for in vitro diagnostic use, exclusively for molecular biology professionals.

Introducing Imegen® Huntington Disease Kit for In Vitro Diagnostic Use:

Product Overview: Imegen® Huntington Disease Kit enables semi-quantitative analysis of CAG expansion in the HTT gene through HTT-C and HTT-L PCR assays, covering a 100-500 bp amplification range. It includes a positive control with normal alleles and complies with ISO 13485 and ISO 14001 quality standards.

Key Features:

• Semi-Quantitative CAG Analysis
• Dual PCR Assays (HTT-C and HTT-L)
• Amplification Range: 100-500 bp
• Included Positive Control
• Compatible with Neurodegenerative Disease Assays
• In Vitro Diagnostic
• DNA Requirement: 50 ng per Reaction
• Sample Type: Peripheral Blood
• 2 Reactions per Sample
• Targets: CAG and poly-CCG
• Quick Setup (45 mins)
• PCR Program Duration: 2h 15 mins
• Compatible with Standard Cyclers
• Sequencing with 6-Carboxyfluorescein (6-FAM) and NEDTM

About Huntington’s Disease: Huntington’s Disease is an inherited neurodegenerative disorder causing progressive brain neuron degeneration, impacting motor skills, cognition, and mental health. Diagnosis hinges on CAG triplet repeat analysis, with <26 repeats as normal, 27-35 intermediate, and >36 as pathological.

Imegen® Huntington Kit offers precise CAG expansion analysis with HTT-C (short-range) and HTT-L (long-range) PCR, covering polymorphic poly-CCG fragments. Sequencing via 6-FAM and NEDTM-labeled PCR products separates amplicons for size analysis.

Imegen® Huntington Kit is designed for in vitro diagnostic use, exclusively for molecular biology professional