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The TP53 gene is commonly known as the “guardian of the genome”. This is for its role in regulating cell division and preventing cancer. Mutations in this gene can disable its tumor-suppressing capabilities, leading to various types of cancer including breast, ovarian, and lung cancers. In cancer diagnostics and treatment, TP53 status serves as a crucial marker for prognosis and therapeutic strategy. Understanding the TP53 mutation landscape is vital for clinicians in making informed decisions about treatments like chemotherapy or targeted therapies, as some treatments may be more or less effective depending on TP53 status.