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Myeloproliferative Neoplasms (MPNs) present a significant diagnostic challenge due to their complex genetic landscape. Among these, Essential Thrombocythemia and Primary Myelofibrosis have been especially difficult to diagnose. Traditional methods are often cumbersome, time-consuming, and prone to inaccuracies. That’s where our CALR Mutation Analysis Kit steps in, offering an unparalleled level of precision and efficiency.
Features at a Glance
Highly Specific: Detects insertions and deletions (indels) in exon 9 of the CALR gene.
Comprehensive: Validated using biobank samples, samples diagnosed by other techniques, and synthetic plasmids.
Fast and Reliable: Uses PCR and subsequent capillary electrophoresis for quick and accurate results.
Quality Certified: Complies with ISO 13485 and ISO 14001 standards.
For Professional Use: Ideal for molecular biology professionals in in vitro diagnostic settings.
The CALR gene is a highly conserved gene encoding a calcium-binding protein. Mutations in this gene have been implicated in approximately 70-88% of MPN cases not influenced by JAK2 gene mutations. Through PCR amplification followed by capillary electrophoresis, the test offers qualitative analyses that evaluate these mutations based on the size of the amplification fragments obtained.
In line with our commitment to sustainability, all packaging materials used for this kit are made from 30-100% recycled material.
Your Trusted Partner in MPN Diagnostics
With our CALR Mutation Analysis Kit, you’re not just buying a product; you’re investing in a solution that brings accuracy, efficiency, and reliability to your laboratory’s diagnostic capabilities. Become part of a growing community of labs that have revolutionized their approach to MPN diagnosis.
The kit contents the necessary reagents to perform 33 reactions. The reagents included in the kit are the following: