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CALR mutation kit

Short description

Accurate MPN Diagnostics: The CALR Mutation Kit Unveiled

Unlock unparalleled accuracy in diagnosing Myeloproliferative Neoplasms (MPNs) with our CALR Mutation Kit. This state-of-the-art kit uses PCR and capillary electrophoresis to specifically identify insertions and deletions in exon 9 of the CALR gene.

Ideal for molecular biology professionals, this kit is your next-level solution for rapid and precise MPN diagnosis.

Product highlights

  • Rapid Results
  • Fragment Analysis
  • 5% Detection Limit
  • Positive Control


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CALR mutation kit



Instructions for Use

MSDS CALR mutation kit


For any missing information or if you require additional details, please do not hesitate to contact us. 

Specifications of the CALR mutation kit

CALR Mutation Kit: Precision Diagnostics for MPN

Myeloproliferative Neoplasms (MPNs) present a significant diagnostic challenge due to their complex genetic landscape. Among these, Essential Thrombocythemia and Primary Myelofibrosis have been especially difficult to diagnose. Traditional methods are often cumbersome, time-consuming, and prone to inaccuracies. That’s where our CALR Mutation Analysis Kit steps in, offering an unparalleled level of precision and efficiency.

Features at a Glance

Highly Specific: Detects insertions and deletions (indels) in exon 9 of the CALR gene.
Comprehensive: Validated using biobank samples, samples diagnosed by other techniques, and synthetic plasmids.
Fast and Reliable: Uses PCR and subsequent capillary electrophoresis for quick and accurate results.
Quality Certified: Complies with ISO 13485 and ISO 14001 standards.
For Professional Use: Ideal for molecular biology professionals in in vitro diagnostic settings.

The CALR gene is a highly conserved gene encoding a calcium-binding protein. Mutations in this gene have been implicated in approximately 70-88% of MPN cases not influenced by JAK2 gene mutations. Through PCR amplification followed by capillary electrophoresis, the test offers qualitative analyses that evaluate these mutations based on the size of the amplification fragments obtained.

In line with our commitment to sustainability, all packaging materials used for this kit are made from 30-100% recycled material.

Your Trusted Partner in MPN Diagnostics

With our CALR Mutation Analysis Kit, you’re not just buying a product; you’re investing in a solution that brings accuracy, efficiency, and reliability to your laboratory’s diagnostic capabilities. Become part of a growing community of labs that have revolutionized their approach to MPN diagnosis.

Components of the CALR mutation kit

The kit contents the necessary reagents to perform 33 reactions. The reagents included in the kit are the following:

  • CALR Master Mix: Buffer, MgCl2, dNTPs, DMSO, specific oligonucleotides and water reagents for
    the PCR reactions.
  • Taq: Conventional PCR enzyme containing 50% glycerol and buffers.
  • Positive Control: Positive control with the wild type of sequence of CALR gene and the
    following mutated pathogenic genotypes in the same gene: deletion of 52pb, insertion of 5pb
    and deletion of 1pb.

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