Imegen-Coeliac Immune PCR kit is a cutting-edge genetic testing solution designed to identify specific genetic markers associated with celiac disease. This innovative product streamlines the diagnostic process for researchers and lab technicians, enabling the identification of individuals at an increased risk of developing celiac disease.
With this kit the detection of the following most common alleles associated with higher susceptibility are possible:
· DQ2.5: HLA-DQA1*05 / HLA-DQB1*02
· DQ2.2: HLA-DQA1*02 / HLA-DQB1*02
· DQ8: HLA-DQA1*03 / HLA-DQB1*03:02
· DQ7.5: HLA-DQA1*05 / HLA-DQB1*03:01
· Allele load analysis for allele HLA-DQB1*02
Celiac Disease Introduction:
Celiac disease, an autoimmune disorder triggered by gluten consumption, affects millions worldwide. The quest to understand its genetic basis has been a focal point in research. In this pursuit, Imegen-Coeliac emerges as a revolutionary product, offering cutting-edge diagnostic solutions for researchers and lab technicians dedicated to unraveling the mysteries of celiac disease.
Understanding Imegen-Coeliac:
Imegen-Coeliac is a state-of-the-art genetic testing solution designed to identify specific genetic markers associated with celiac disease. With a focus on human leukocyte antigen (HLA) genes, particularly HLA-DQ2 and HLA-DQ8, Imegen-Coeliac enables researchers to pinpoint individuals at an increased risk of developing celiac disease. This breakthrough technology streamlines the diagnostic process, providing invaluable insights into the genetic predispositions that contribute to the disease’s onset.
Advantages for Researchers:
Imegen-Coeliac offers researchers a powerful tool to delve into the genetic landscape of celiac disease. By accurately identifying individuals with genetic predispositions to celiac disease, researchers can stratify study cohorts effectively. This enhanced precision allows for more targeted investigations, helping to elucidate the complex interactions between genetic and environmental factors involved in the disease’s pathogenesis.
Enhancing Lab Efficiency:
For lab technicians, Imegen-Coeliac streamlines the genetic testing process, reducing turnaround times without compromising accuracy. The kit comes equipped with all necessary materials and detailed instructions, ensuring seamless sample collection and processing. As a result, laboratories can expedite results delivery, empowering healthcare professionals with actionable data to facilitate early detection and personalized treatment strategies.
Unleashing the Potential of Personalized Medicine:
Imegen-Coeliac’s advanced capabilities resonate with the principles of personalized medicine. Armed with comprehensive genetic data, clinicians can tailor treatments to meet the unique needs of patients with celiac disease. This shift towards personalized medicine promises improved patient outcomes, enhanced treatment adherence, and a reduced burden on healthcare resources.
Conclusion:
Imegen-Coeliac stands at the forefront of celiac disease research, accelerating our understanding of its genetic underpinnings. For researchers and lab technicians, this revolutionary product offers an indispensable tool to unlock the mysteries of celiac disease. As we embrace the power of personalized medicine, Imegen-Coeliac holds the potential to transform how we diagnose, treat, and manage this prevalent autoimmune disorder, ultimately improving the lives of individuals living with celiac disease worldwide.
This kit contains sufficient reagents to perform 48 real-time PCR reactions with each premaster analyzed in this assay. The reagents included in this kit are as follows:
Coeliac Master Mix I: PCR-specific Master Mix containing the oligonucleotides and fluorescent hydrolysis probes (FAMTM and VICTM) that allow for the simultaneous detection of allele HLA-DQA1*05 and the endogenous gene β-globin, respectively, with the latter serving as endogenous PCR control.
Coeliac Master Mix II: PCR-specific Master Mix containing the oligonucleotides and fluorescent hydrolysis probes (FAMTM and VICTM) that allow for simultaneous discrimination between allele HLA-DQB1*02 and the remaining HLA-DQB1 alleles.
Coeliac Master Mix III: PCR-specific Master Mix containing the oligonucleotides and fluorescent hydrolysis probes (FAMTM and VICTM) that allow for simultaneous discrimination between allele DQB1*03:02 and allele HLA-DQA1*03, respectively.
Coeliac Master Mix IV: PCR-specific Master Mix containing the oligonucleotides and fluorescent hydrolysis probes (FAMTM and VICTM) that allow for simultaneous discrimination between allele DQA1*02 and allele DQB1*03:01, respectively.
Master Mix General: PCR master mix with the nucleotides, MgCl2, enzyme and buffer required to perform real-time PCR.
Positive control: synthetic DNA containing the sequences of the amplified regions matching all the alleles included in the kit.
Goffin Molecular Technologies is a leading Dutch company with a rich history, offering a diverse range of high-quality molecular diagnostics products from various manufacturers.
