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The Apo E StripAssay kit from Viennalab is a highly sensitive and specific test that allows for the rapid identification of Apo E gene variants, including the three most common alleles: E2, E3, and E4. These gene variants are associated with varying levels of risk for Alzheimer’s disease and other neurological disorders. The assay is based on a reverse hybridization method, which allows for the simultaneous detection of multiple alleles in a single reaction.
The Apo E StripAssay kit from Viennalab provides a reliable and accurate method for identifying the three common alleles of the apolipoprotein E (Apo E) gene: ε2, ε3, and ε4. These alleles are known to be associated with different risk profiles for cardiovascular disease and Alzheimer’s disease. Using the PCR-reverse hybridization technique, this assay allows for the simultaneous detection and differentiation of the three alleles in a clinical sample. The procedure is quick, taking less than two hours, and involves PCR amplification followed by hybridization to allele-specific probes immobilized on strips.
The Apo E gene, located on chromosome 19, plays a crucial role in lipid metabolism, with the three alleles differing by single nucleotide polymorphisms (SNPs) at specific positions. These genetic variations affect the function of the protein, influencing the risk of diseases such as Alzheimer’s and cardiovascular conditions. The kit includes all necessary components, ensuring ease of use for clinical laboratories. Besides its clinical applications, the Apo E StripAssay has been valuable in research studies, particularly in exploring the link between Apo E genotypes and disease risks, such as the increased likelihood of Alzheimer’s in ε4 carriers or the protective effect of the ε2 allele.
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